Seeing is believing, PLGA microsphere degradation revealed in PLGA microsphere/PVA hydrogel composites
نویسندگان
چکیده
منابع مشابه
Controlling acute inflammation with fast releasing dexamethasone-PLGA microsphere/pva hydrogel composites for implantable devices.
BACKGROUND Continuous release of dexamethasone from PLGA microsphere/PVA hydrogel composites has been shown to suppress the inflammatory tissue reaction in response to subcutaneously implanted foreign material for a period of one month. The scope of the present work is to investigate whether suppressing the initial acute inflammatory phase with fast releasing dexamethasone-PLGA microsphere/PVA ...
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Polymer degradation and drug release kinetics from PLGA microspheres were investigated under neutral and acidic pH conditions. Two different Mw formulations (Mw: 25,000 and 70,000) were investigated and both exhibited a triphasic release profile at pH 7.4 as well as at pH 2.4. The initial burst and lag phases were similar for both pH values, while the secondary apparent-zero-order phase was sub...
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The aim of this study was to evaluate the effect of PLGA microsphere dimensions on bone formation after injection of calcium phosphate cement (CPC)/PLGA in a guinea pig tibial intramedullarly model. To this end, injectable CPC/PLGA formulations were prepared using PLGA microspheres with either a small (~25 µm) or large (~100 µm) diameter, which were incorporated at a 20:80 ratio (wt%) within ap...
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Doctors and the public considerably underestimate the negative impact of age related macular degeneration (ARMD) on health related quality of life. (Br J Ophthalmol 2003;87:8–12) The progressive nature of ARMD prevents participation in many everyday activities, such as reading and driving, and it is also the most common cause of blindness in elderly people. A standardised questionnaire created ...
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For many of our patients, “seeing is believing.” In fact, some of the most tangible discussions about cancer are centered on an X-ray image. The X-ray image, brightly lit from behind, historically has given a physical quality to the relatively nebulous term “cancer.” Imaging studies in many solid organ cancers have improved to the point that we consider their presence on film to be vital part o...
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ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2016
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2016.03.011